[Therapy of cardio-neurotic diseases in general practice: clinical experience with atarax]. / Terapiia kardionevroticheskikh rasstroist v obshcheterapevticheskoi praktike: opyt primeneniia ataraksa.

An open study of efficiency and safety of atarax (hydroxisine) enrolled 55 outpatients (23 males and 32 females, mean age 45.91 +/- 1.91) with generalized anxious and somatoform disorders running as cardioneurosis as well as nosogenic reactions (maladaptation), manifestations of cardiovascular pathology (acute myocardial infarction, angina of effort functional class II-III, postinfarction cardiosclerosis, essential hypertension in 5, 13, 2 and 5 patients, respectively). The patients received atarax for 28 days (daily dose 50 mg). The course was completed in 54 patients. In 47 of them, the overall score value by Hamilton Anxiety Scale dropped by 10 scores, the reduction being more obvious in patients with somatic anxiety. Hydroxysine is well tolerated and safe both in patients with somatic pathology and those with cardiovascular disorders.

[The clinical and psychological aspects of the reaction to disease (the problem of nosogenias)]. / Klinicheskie i psikhologicheskie aspekty reaktsii na bolezn' (k probleme nozogenii).

"Nosogenias" is the term describing some reactive states. They account for 15-90% of all the patients of somatic hospital. They are due to constellation of some psychotraumatic events related to somatic disease. A total of 166 patients were examined, among them 55 patients with ischemic heart disease, 56 cases with hypertension and 56 ones with bronchial asthma. The results evidence for the existence of two independent vectors which characterise "extremal" points of continuum of disease perception. The importance of somatic trouble (hyper- or hyponosognomia) was the basis of the first vector while the degree of completeness of independent and the whole image of disease as something which differed from "self" (ego-dystonic and ego-syntonic perception of disease) was the basis of the second vector. Combination of the above vectors with clinical and psychological characteristics in the whole clinical pattern of disease was recorded.

[A trial of the use of the preparation Arthrotec for treating rheumatic diseases]. / Opyt primeneniia preparata atrotek dlia lecheniia revmaticheskikh zabolevanii.

A clinical trial of arthrotek (Searle) in 60 RA patients aged 16-77 years demonstrated its high anti-inflammatory activity in 47 of them. These patients have received a complete treatment course, 10 patients were not included in the overall estimations because of side affects (gastric pains and nausea) causing them to withdraw early in the treatment course, 3 patients were nonresponders. The responders experienced attenuation of joint pain, morning stiffness. Inflammation in some joints declined, the articular index decreased.

[Effect of nitroglycerine on cerebral blood flow and central hemodynamics in patients with chronic heart failure]. / Vliianie nitroglitserina na mozgovoi krovotok i tsentral'nuiu gemodinamiku u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu.

The study of the cerebral and central hemodynamics by tetrapolar and chest rheography in 53 patients with various stages of chronic heart failure has shown that the intravenous injection of nitroglycerin exerts a marked vasodilating peripheral effect in patients with pronounced cardiac failure while having no significant influence on cardiac output. The cerebral blood flow increases following nitroglycerin injection which permits recommending the drug for use to improve the cerebral hemodynamics in patients with severe forms of cardiac failure.

[Effect of psychotropic preparations on the activity of transport ATPase of rabbit skeletal muscle sarcoplasmic reticulum]. / Vliianie psikhotropnykh preparatov na aktivnost' transportnoi ATF-asy sarkoplazmaticheskogo retikuluma skeletnykh myshts krolika

The effect exerted by 5 groups of psychotropic agents on b activity of Ca, Mg-dependent ATP-ase of the sarcoplasmatic reticulum in the skeletal muscles of the rabbit and the transport of Ca2+ were looked into. The most profound inhibitory effect was found to be displayed by neuroleptics--phenothiazine derivatives with the piperazine ring in the side chain. Neuroleptics-butyrophenones produced a much less marked inhibitory action. Tricyclic antidepressants noticeably reduced the activity of the enzyme, while MAO inhibitors proved little effective in this respect. Tranquilizers--benzodiazepine derivatives--displayed a moderate inhibitory influence, while trioxazine turned out to be little active. The stimulants caffein, pentylene tetrazol (corazol), as well as high concentrations of lithium salts raised, whereas their low concentrations suppressed the activity of the enzyme. The inhibitory effect of psychotropic agents increased by as much s 11/2--2 times with regard to the enzyme preliminarily activated through incubation with ATP.

[Effect of psychotropic preparations on the activity of Ca- and Mg-dependent ATPase of the sarcoplasmic reticulum]. / Vliianie psikhotropnykh preparatov na aktivnost' Ca, Mg-zavisimoi ATF-azy sarkoplazmaticheskogo retikuluma

In sarcoplasmic reticulum of rabbit skeletal muscles the activity of Ca2+, Mg2+- dependent ATPase was distinctly inhibited under effect of neuroleptic drugs - derivatives of phenothiazine and butyrophenone. The effect of tricyclic antidepressants was less pronounced. Tranquilizers (derivatives of 1,4-benzodiazepine) inhibited the enzyme, but trioxazin was only slightly active. High concentrations of lithium salts and of psychostimulants caffeine and corasole were found to stimulate the Ca2+, Mg2+-ATPase activity; low concentrations of the substances slightly inhibited the enzyme. The blocking effect of psychotropic drugs was more distinct, if the enzyme preparations were previously treated with ATP.